African Collections

Samples and data from African collections available through collaboration with the study PI Dr. Jeff Martin.
  • Antiretrovirals in Kaposi Sarcoma (ARKS)
  • Uganda AIDS Rural Treatment Outcomes (UARTO)
  • Epidemiology and Virology of KSHV in Zimbabwe
  • Transmission of KSHV to Children in South Africa
 

Antiretrovirals in Kaposi Sarcoma (ARKS): A randomized trial conducted from 2007 to 2011 to evaluate the efficacy of a protease inhibitor-based antiretroviral therapy regimen compared with a non-nucleoside reverse transcriptase inhibitor-based regimen to treat HIV-related histologically-confirmed KS in adults in Uganda. Data and biospecimens collected at multiple time points  from this cohort of >200 participants are depicted in the graphic. Click here for STUDY DETAILS

Uganda AIDS Rural Treatment Outcomes (UARTO): 
A prospective cohort study conducted from 2005 to 2010 to describe the virologic, immunologic, and clinical outcomes of antiretroviral therapy and factors associated with these outcomes among >700 adults recruited from a representative publicly funded municipal HIV/AIDS clinic in Mbarara, Uganda.  Specimens collected at multiple time points are depicted in the graphic. Click here for STUDY DETAIL

Epidemiology and Virology of KSHV in Zimbabwe: 
A cross-sectional study conducted from 2001 to 2004 that evaluated the prevalence and determinants of KSHV infection and the pattern of KSHV shedding among >500 HIV+ and HIV- adult women in Zimbabwe. Specimens collected at are depicted in the graphic. Click here for STUDY DETAIL

Transmission of KSHV to Children in South Africa: A cross-sectional study conducted in 2001 to 2004 that evaluated the prevalence and determinants of KSHV infection and shedding among >900 HIV+ and HIV- children aged 1.5 to <9 years and their primary caregiver in rural and urban settings in Africa. Available specimens are depicted in the graphic. Click here for STUDY DETAIL

Domestic Collections

ACSR Domestic Collection.

  • Women’s Interagency HIV Study (WIHS) donations
  • San Francisco Young Men’s Health Study (SFYMHS)

 

Women’s Interagency HIV Study (WIHS) donations: 
A longitudinal cohort study of HIV+ and HIV- adult women to characterize the long-term, natural and treated history of HIV infection and to provide insight into the changing demographics of the HIV epidemic in the United States. Data and biospecimen donations from 1400 women were collected at multiple time points from 200X to 200X. Available biospecimens are depicted in the graphic. Click here for STUDY DETAIL

San Francisco Young Men’s Health Study: 
A population-based epidemiological risk factor study conducted from 1992 to 199X among adult men who have sex with men in San Francisco. The cohort includes 581 men of varying status for HIV infection, KSHV infection, and KS. Data and biospecimens were collected at multiple time points. Available specimens are depicted in the graphic. Click here for STUDY DETAIL

Multisite Autopsy Collections

The ACSR has a collection of multi-site frozen/FFPE autopsies as a novel source of tissues from 57 HIV/AIDS patients with malignancies and other conditions.  Autopsy specimens are available from a spectrum of patients, many within 6 hours of death, and most with multiple sites collected from cancer involved tissues as well as control uninvolved tissues.

Specimens available for Multisite Autopsy Collections.

General Collections

In Progress

Specimens available for General Collections.

Tissue Microarrays (TMAs)

Investigators requesting access to view Tissue Microarray (TMA) images for their research are required to complete the ACSR’s Image Access Agreement.

KS (HIV related) oral, visceral and skin from the U.S. and sub-Saharan Africa (SSA).  Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

  • Oral: 24 cores from 19 patients (4 control cores) Aperio Image / Detail Image Detail
  • Visceral: 33 cores from 28 patients (4 control cores) Aperio Image / Detail ImageDetail
  • Skin: 36 cores from 31 patients (4 control cores) Aperio Image / Detail Image Detail
  • SSA Oral: 12 cores from 9 patients (4 control cores) Aperio Image / Detail
  • SSA Visceral: 12 cores from 9 patients (2 control cores) Aperio Image / Detail
  • SSA Visceral: 11 cores from 8 patients (4 control cores) Aperio Image / Detail
  • SSA Skin: 31 cores from 28 patients (2 control cores) Aperio Image / Detail
  • SSA Skin: 30 cores from 27 patients (2 control cores) Aperio Image / Detail
  • SSA Skin: 12 cores from 9 patients (2 control cores) Aperio Image / Detail

Lymphoma (HIV related) from the U.S. Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

  • DLBCL HIV+: 13 cores from 10 cases (2 control cores) Aperio Image / Detail
  • DLBCL HIV+: 14 cores from 10 cases (2 control cores) Aperio Image / Detail
  • DLBCL HIV+: 58 cores from 54 cases (3 control cores) Aperio Image / Detail & Image / Detail

 

Lymphoma ( HIV-) from the U.S. Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

  • DLBCL HIV-: 43 cores from 38 cases (4 control cores) Aperio Image / Detail & Image / Detail
  • Post-transplant Lymphoproliferative disorder (PTLD): 23 cores from 22 cases (1 control core) Aperio Image / Detail Image / Detail
  • Misc Lymphoma: 56 cores from 52 cases (3 control cores) Aperio Image / Detail
  • Misc lymphoma: 55 cores from 52 cases (2 control cores) Aperio Image / Detail

 

Non-AIDS-defining Cancers (HIV related) from the U.S. Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

  • Anal Cancer HIV+ Invasive: 40 cores from 36 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ Invasive: 14 cores from 10 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ In situ: 23 cores from 19 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ In situ: 11 cores from 7 cases (3 control cores) Aperio Image / Detail
  • Lung Cancer HIV+: 28 cores from 27 cases (1 control core) Aperio Image / Detail
  • Lung Cancer HIV+: 27 cores from 26 cases (1 control core) Aperio Image / Detail
  • Prostate Cancer HIV+: 22 cores from 20 cases (2 control cores) Aperio Image / Detail
  • Prostate Cancer HIV+: 20 cores from 18 cases (2 control cores) Aperio Image / Detail

Multsite Autopsies - HIV related non-Hodgkin lymphoma (NHL) includes involved and uninvolved tissues. Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

 

Multsite Autopsies - HIV related Kaposi Sarcoma (KS) includes involved and uninvolved tissues. Examples of TMA Aperio images are provided in the first TMA below.  Please go to Aperio for the complete collection of TMA images.

  • KS: 19 cores from 18 sites (1 control core) Aperio Image/ Detail
  • KS: 18 cores from 17 sites (1 control core) Aperio Image / Detail
  • KS: 16 cores from 15 sites (1 control core) Aperio Image / Detail
  • KS: 25 cores from 24 sites (1 control core) Aperio Image / Detail
  • KS: 20 cores from 19 sites (1 control core) Aperio Image / Detail Image Detail
  • KS: 22 cores from 21 sites (1 control core) Aperio Image / Detail
  • KS: 21 cores from 20 sites (1 control core) Aperio Image / Detail