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Publications
Research Projects
A variety of funded research protocols have used the ACSR's HIV and non-HIV infected tissues. More than 1400 specimens have been awarded to 50 approved researchers worldwide since the beginning of 1996. These specimens were from patients with AIDS-related lymphoma, KS, anogenital disease and lung cancer. The broad type of studies performed using ACSR specimen include the following:
  • Search for specific or novel viruses in cancer tissue
  • Examine the role of chemokines, cytokines and growth factors in cancer
  • Study the contribution of chronic B-cell stimulation to B-cell lymphomas
  • Search for genomic/chromosomal changes (some virally mediated) or changes in gene expression profiles
  • Diagnostic assay development and validation
  • Search for markers of oncogene activation
  • Effect of HIV integration site on cancer development
  • Mechanisms of resistance and susceptibility to antiviral agents
  • Identification of viral CTL epitopes

Results of selected studies:

First description of angiogenic responses associated with in vivo growth of HHV-8+ PEL cells transplanted into SCID mice. Subsequent studies by other investigators indicated that PEL cells secrete VEGF and that HHV-8 vIL-6 may contribute to the pathogenesis of these infusion lymphomas via VEGF stimulation and subsequent increases in vascular permeability.

Molecular evidence of the polyclonality in HIV associated polyclonal lymphoma, qualitative differences in somatic hypermutations of Ig V(H) genes associated with malignant versus B-cell lymphompropliferations. Subsequent work using SCID mice injected with BCBL-1 cells revealed an association of large cell lymphomas with human macrophages supporting the macrophage initiated sequential pathogenesis model of lymphomagenesis.

HIV+ individuals have aberrant and unstable expression of Ig genes suggestive of a high degree of humoral immune dysregulation and ongoing humoral immune responses to HIV-associated antigens. Results were consistent with the hypothesis that rapid B-cell turnover due to antigenic stimulation may result in somatic mutations leading to malignant transformation.

Widespread genomic instability, manifested by increase frequency of micro satellite alterations, was greatly increased in HIV+ patients with lung cancer.

Impaired cellular capacity of KS cells to degrade oxidants resulting in intracellular retention of reactive oxygen intermediates and subsequent oxidant stress. This perturbation results in increased responsiveness to TNF-a which may cause a feedback growth signaling loop in KS cells.

Using a variety of in situ techniques, HHV-8 gene expression and virion localization was demonstrated within endothelial cells of KS lesions.

Several genes of HHV-8 were indentified including the immunodominant K8.1 viral glycoprotein subsequently employed in development of sensitive and specific serologic assays. Latent messages encoded with the ORF K15 were identified; one is related to the EBV LMP2 gene, a target for immunotherapy.

Development, calibration and validation of HHV-8 immunoassays.

Four distinct subtypes of HHV-8 were identified that clustered by geographic location implicating that HHV-8 is an ancient human virus preferentially transmitted vertically in a familial fashion and is difficult to transmit horizontally in the absence of immune supporesion. Subsequent virus transmission by others have supported these results.
Publications
  1. Przybylski GK, Goldman J, Ng VL, McGrath MS, Herndier BG, Schenkein DP, Monroe JG, Silberstein LE. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood. 1996 Dec 15;88(12):4620-9. link
  2. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, Haase AT. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997 Jan;71(1):715-9. link
  3. Ng VL, Hurt MH, Herndier BG, Fry KE, McGrath MS. VH gene use by HIV type 1-associated lymphoproliferations. AIDS Res Hum Retroviruses. 1997 Jan 20;13(2):135-49. link
  4. Orenstein JM, Alkan S, Blauvelt A, Jeang KT, Weinstein MD, Ganem D, Herndier B. Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS. 1997 Apr;11(5):F35-45. link
  5. Holly EA, Lele C, Bracci P. Non-Hodgkin's lymphoma in homosexual men in the San Francisco Bay Area: occupational, chemical, and environmental exposures. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jul 1;15(3):223-31. link
  6. Picchio GR, Sabbe RE, Gulizia RJ, McGrath M, Herndier BG, Mosier DE. The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft. Virology. 1997 Nov 10;238(1):22-9. link
  7. Mallery SR, Landwehr DJ, Ness GM, Clark YM, Hohl CM. Thiol redox modulation of tumor necrosis factor-alpha responsiveness in cultured AIDS-related Kaposi's sarcoma cells. J Cell Biochem. 1998 Mar 1;68(3):339-54. link
  8. Palefsky JM, Holly EA, Hogeboom CJ, Ralston ML, DaCosta MM, Botts R, Berry JM, Jay N, Darragh TM. Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):314-9. link
  9. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med. 1998 Apr 2;338(14):948-54.
  10. Wistuba II, Behrens C, Milchgrub S, Virmani AK, Jagirdar J, Thomas B, Ioachim HL, Litzky LA, Brambilla EM, Minna JD, Gazdar AF. Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects. JAMA. 1998 May 20;279(19):1554-9. link
  11. Li M, MacKey J, Czajak SC, Desrosiers RC, Lackner AA, Jung JU. Identification and characterization of Kaposi's sarcoma-associated herpesvirus K8.1 virion glycoprotein. J Virol. 1999 Feb;73(2):1341-9. link
  12. Orenstein JM, Wahl SM. The macrophage origin of the HIV-expressing multinucleated giant cells in hyperplastic tonsils and adenoids. Ultrastruct Pathol. 1999 Mar-Apr;23(2):79-91. link
  13. Mallery SR, Clark YM, Ness GM, Minshawi OM, Pei P, Hohl CM. Thiol redox modulation of doxorubicin mediated cytotoxicity in cultured AIDS-related Kaposi's sarcoma cells. J Cell Biochem. 1999 May 1;73(2):259-77. link
  14. Zong JC, Ciufo DM, Alcendor DJ, Wan X, Nicholas J, Browning PJ, Rady PL, Tyring SK, Orenstein JM, Rabkin CS, Su IJ, Powell KF, Croxson M, Foreman KE, Nickoloff BJ, Alkan S, Hayward GS. High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. J Virol. 1999 May;73(5):4156-70. link
  15. Poole LJ, Zong JC, Ciufo DM, Alcendor DJ, Cannon JS, Ambinder R, Orenstein JM, Reitz MS, Hayward GS. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J Virol. 1999 Aug;73(8):6646-60. link
  16. Holly EA, Lele C, Bracci PM, McGrath MS. Case-control study of non-Hodgkin's lymphoma among women and heterosexual men in the San Francisco Bay Area, California. Am J Epidemiol. 1999 Aug 15;150(4):375-89. link
  17. McGrath MS, Shiramizu B, Herndier BG. Clonal HIV in the pathogenesis of AIDS-related lymphoma. In Infectious Causes of Cancer Targets for Intervention. Edited by Goedert JJ. New Jersey: Humana Press. 2000:231-242. link
  18. Aoki Y, Tosato G, Nambu Y, Iwamoto A, Yarchoan R. Detection of vascular endothelial growth factor in AIDS-related primary effusion lymphomas. Blood. 2000 Feb 1;95(3):1109-10. link
  19. Martin JN, Amad Z, Cossen C, Lam PK, Kedes DH, Page-Shafer KA, Osmond DH, Forghani B. Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies. J Clin Microbiol. 2000 Feb;38 (2):696-701. link
  20. Edelman DC, Ketema F, Saville RD, Herman J, Sill AM, Gill PS, Blattner WA, Constantine NT. Specifics on the refinement and application of two serological assays for the detection of antibodies to HHV-8. J Clin Virol. 2000 May;16(3):225-37. link
  21. Osmond DH, Catania J, Pollack L, Canchola J, Jaffe D, MacKellar D, Valleroy L. Obtaining HIV test results with a home collection test kit in a community telephone sample. J Acquir Immune Defic Syndr. 2000 Aug 1;24(4):363-8.
  22. Aoki Y, Yarchoan R, Braun J, Iwamoto A, Tosato G. Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions. Blood. 2000 Aug 15;96(4):1599-601. link
  23. Mallery SR, Pei P, Kang J, Ness GM, Ortiz R, Touhalisky JE, Schwendeman SP. Controlled-release of doxorubicin from poly(lactide-co-glycolide) microspheres significantly enhances cytotoxicity against cultured AIDS-related Kaposi's sarcoma cells. Anticancer Res. 2000 Sep-Oct; 20(5A):2817-25. link
  24. Mallery SR, Pei P, Kang J, Zhu G, Ness GM, Schwendeman SP. Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts. Carcinogenesis. 2000 Sep;21(9):1647-53. link
  25. Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med. 2001 Jan;7(1):73-9. link
  26. Osmond DH, Buchbinder S, Cheng A, Graves A, Vittinghoff E, Cossen CK, Forghani B, Martin JN. Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA. 2002 Jan 9;287(2):221-5.
  27. Vilchez RA, Lednicky JA, Halvorson SJ, White ZS, Kozinetz CA, Butel JS. Detection of polyomavirus simian virus 40 tumor antigen DNA in AIDS-related systemic non-Hodgkin lymphoma. J Acquir Immune Defic Syndr. 2002 Feb 1;29(2):109-16. link
  28. McGrath MS, Kahn JO, Herndier BG. Development of WF10, a novel macrophage-regulating agent. Curr Opin Investig Drugs. 2002 Mar;3(3):365-73. link
  29. Vilchez RA, Madden CR, Kozinetz CA, Halvorson SJ, White ZS, Jorgensen JL, Finch CJ, Butel JS. Association between simian virus 40 and non-Hodgkin lymphoma. Lancet. 2002 Mar 9;359(9309):817-23. link
  30. Lore K, Sonnerborg A, Brostrom C, Goh LE, Perrin L, McDade H, Stellbrink HJ, Gazzard B, Weber R, Napolitano LA, van Kooyk Y, Andersson J. Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS. 2002 Mar 29;16(5):683-92. link
  31. Gascon RL, Narvaez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS. Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion. J Acquir Immune Defic Syndr. 2002 Jun 1;30(2):146-53. link
  32. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood. 2003 Jan 15;101(2):466-8. Epub 2002 Sep 5. link
  33. Zenger E, Abbey NW, Weinstein MD, Kapp L, Reis J, Gofman I, Millward C, Gascon R, Elbaggari A, Herndier BG, McGrath MS. Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas. Cancer Res. 2002 Oct 1;62(19):5536-42. link
  34. Ghosh SK, Wood C, Boise LH, Mian AM, Deyev VV, Feuer G, Toomey NL, Shank NC, Cabral L, Barber GN, Harrington WJ Jr. Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-kappa B. Blood. 2003 Mar 15;101(6):2321-7. Epub 2002 Oct 24.
  35. Spiller OB, Robinson M, O'Donnell E, Milligan S, Morgan BP, Davison AJ, Blackbourn DJ. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. J Virol. 2003 Jan;77(1):592-9. link
  36. Romer DJ, Suster S. Use of virtual microscopy for didactic live-audience presentation in anatomic pathology. Ann Diagn Pathol. 2003 Feb;7(1):67-72. link
  37. Ruff K, Baskin GB, Simpson L, Murphey-Corb M, Levy LS. Rhesus rhadinovirus infection in healthy and SIV-infected macaques at Tulane National Primate Research Center. J Med Primatol. 2003 Feb;32(1):1-6. link
  38. Dittmer DP. Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays. Cancer Res. 2003 May 1;63(9):2010-5. link
  39. Mallery SR, Morse MA, Wilson RF, Pei P, Ness GM, Bradburn JE, Renner RJ, Schuller DE, Robertson FM. AIDS-related Kaposi's sarcoma cells rapidly internalize endostatin, which co-localizes to tropomysin microfilaments and inhibits cytokine-mediated migration and invasion. J Cell Biochem. 2003 May 1;89(1):133-43. link
  40. Romer DJ, Yearsley KH, Ayers LW. Using a modified standard microscope to generate virtual slides. Anat Rec B New Anat. 2003 May;272(1):91-7. link
  41. Engels EA, Pittaluga S, Whitby D, Rabkin C, Aoki Y, Jaffe ES, Goedert JJ. Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirus” in Mod Pathol. 2003 May;16(5):424-9.
  42. Haque M, Davis DA, Wang V, Widmer I, Yarchoan R. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia. J Virol. 2003 Jun;77(12):6761-8. link
  43. Mack KD, Jin X, Yu S, Wei R, Kapp L, Green C, Herndier B, Abbey NW, Elbaggari A, Liu Y, McGrath MS. HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression. J Acquir Immune Defic Syndr. 2003 Jul 1;33(3):308-20. link
  44. Chaves AA, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Ayers LW, Bauer JA. Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in human HIV/AIDS cardiac tissues. Cardiovasc Res. 2003 Oct 15;60(1):108-18. link
  45. Pulliam L , Sun, B, Rempel, H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J. Neuroimmunol. (2004) 157:93-98 link
  46. Killebrew DA, Troelstrup D, Shiramizu B. Preferential HIV-1 integration sites in macrophages and HIV-associated malignancies. Cell Mol Biol (Noisy-le-grand). 2004;50 Online Pub:OL581-9. link
  47. Milligan S, Robinson M, O'Donnell E, Blackbourn DJ. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells. J Virol. 2004 Mar;78(5):2591-6. link
  48. Mallery SR, Pei P, Landwehr DJ, Clark CM, Bradburn JE, Ness GM, Robertson FM. Implications for oxidative and nitrative stress in the pathogenesis of AIDS-related Kaposi's sarcoma. Carcinogenesis. 2004 Apr;25(4):597-603. Epub 2003 Dec 4. link
  49. McAllister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Fruh K, Moses AV. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood. 2004 May 1;103(9):3465-73. Epub 2004 Jan 15. link
  50. Giese T, McGrath MS, Stumm S, Schempp H, Elstner E, Meuer SC. Differential effects on innate versus adaptive immune responses by WF10. Cell Immunol. 2004 Jun;229(2):149-58. link
  51. Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T, Elliman S, Flanagan AM, Alitalo K, Boshoff C. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004 Jul;36(7):687-93. Epub 2004 Jun 27 link
  52. Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T, Elliman S, Flanagan AM, Alitalo K, Boshoff C. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004 Jul;36(7):687-93. Epub 2004 Jun 27. link
  53. Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, Narvaez AB, Hunt P, Martin JN, Kahn JO, Levy J, McGrath MS, Hecht FM. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood. 2004 Aug 15;104(4):942-7. Epub 2004 Apr 29. link
  54. Zhang R, Gascon R, Miller RG, Gelinas DF, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS. Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol. 2005 Feb;159(1-2):215-24. Epub 2004 Nov 26. link
  55. Kurokawa M, Ghosh SK, Ramos JC, Mian AM, Toomey NL, Cabral L, Whitby D, Barber GN, Dittmer DP, Harrington WJ Jr. Azidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphoma. Blood. 2005 Jul 1;106(1):235-40. Epub 2005 Mar 24. link
  56. Marchiò S., Alfano M., Primo L., Gramaglia D., Butini L., Gennero L., De Vivo E., Arap W., Giacca M., Pasqualini R., Bussolino F.: Cell Surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood 2005 Apr 1; 105(7):2802-11 link
  57. Marchiò S, Alfano M, Primo L, Gramaglia D, Butini L, Gennero L, De Vivo E, Arap W, Giacca M, Pasqualini R, Bussolino F Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood. 2005 Apr 1;105(7):2802-11. Epub 2004 Dec
  58. Orem J, Otieno MW, Banara C, Katongoli-Mbidde E, Johnson JL, Ayers L, Ghannoum M, Fu P, Feigal EG, Black J, Whalen G, Lederman M, Remick SC. Capacity Building for the Clinical Investigation of AIDS Maligancy in East Africa. Cancer Detection and Prevention. 2005 April 26;29(2):133-4 link
  59. Nohle DG, Ayers LW. The tissue microarray data exchange specification: a document type definition to validate and enhance XML data. BMC Med Inform Decis Mak. 2005 May 4;5(1):12. link
  60. Baliga RS, Chaves AA, Jing L, Ayers LW, Bauer JA. AIDS-related vasculopathy: evidence for oxidative and inflammatory pathways in murine and human AIDS. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1373-H1380. Epub 2005 May 27. link
  61. Salemi M, Lamer SL, Yu S, de Oliveira T, Fitch WM, McGrath MS. Phylodynamic analysis of Human Immunodeficiency Virus Type 1 in Distinct Brain Compartments Provides a Model for the Neuropathogenesis of AIDS. J Virol 2005 Sep;79 (17):11343-11352. link
  62. Nohle DG, Hackman BA, Ayers LW. The tissue micro-array data exchange specification: a web based experience browsing imported data. BMC Med Inform Decis Mak. 2005 Aug 8;5:25. link
  63. Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, and Foreman KE. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi’s sarcoma tumor cells. Oncogene 2005 Sep 22;24:6333−44. link
  64. Randhawa P, Uhrmacher J, Pasculle W, Vats A, Shapiro R, Eghtsead B, Weck K. A comparative study of BK and JC virus infections in organ transplant recipients. J Med Virol. 2005 Oct;77(2):238-43.
  65. Huerta-Yepez S, Vega M, Gui D, Said J, Bonavida B. Analysis of YY1 and XIAP expression, proteins that regulate resistance, in AIDS-NHL tissue arrays. Blood 2005 Dec;106 (11). link
  66. Nikitenko L, Boshoff C. Endothelial cells and cancer. Handb Exp Pharmacol. 2006;(176 Pt 2):307-34. Review.
  67. Krathwohl MD, Schacker TW, and Anderson JL. Abnormal Presence of Semimature Dendritic Cells That Induce Regulatory T Cells in HIV-Infected Subjects. J Infect Dis 2006 Feb 15; 193:494-504 link
  68. Mbulaiteye SM, Katabira ET, Wabinga H, Parkin DM, Virgo P, Ochai R, Workneh M, Coutinho A, Engels EA. Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match Study. Int J Cancer 2006 Feb 15;118(4):985-90 link
  69. Chaves AA, Baliga RS, Mihm MJ, Schanbacher BL, Basuray A, Liu C, Cook AC, Ayers LW, Baurer JA: Bacterial Lipopolysaccharide Enhances Cardiac Dysfunction but Not Retroviral Replication in Murine AIDS: Roles of Macrophage Infiltration and Toll-Like Receptor 4 Expression. Am J Pathol 2006 Mar;168(3):727-735 link
  70. Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B. Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus. Cancer Res. 2006 Apr 1;66(7):3658-66 link
  71. Lamers SL, Salemi T, de Oliveria T, Beason S, Compton R, Goodenow M, McGrath MS. A Protocol for HIV-1 env Alignments Assists in Determining the Evolutionary Dynamics of the V1, V2 and V4 Hypervariable Domains. Submitted to HIV Pathogenesis Symposium, Keystone CO, Mar 27-Apr 2, 2006 Journal of Virology 79 (17):11343-11352 link
  72. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Bathelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. Gene expression and angiotropism in primary CNS lymphoma. Blood 2006;107:3716-3723 link
  73. You J, Srinivasan V, Denis GV, Harrington WJ Jr, Ballestas ME, Kaye KM, Howley PM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep;80(18):8909-19.
  74. R Newton, L Carpenter, D Casabonne, V Beral, A Babiker, J Darbyshire, I Weller, R Weiss, A Kwan, D Bourboulia, F Munoz, D Lagos and C Boshoff. A prospective study of Kaposi’s sarcoma-associated herpesvirus and Epstein–Barr virus in adults with human immunodeficiency virus-1. British Journal of Cancer (2006) 94, 1504 – 1509 link
  75. Laney AS, Peters JS, Manzi SM, Kingsley LA, Chang Y, Moore PS. Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol. 2006 Oct;44(10):3734-41.
  76. Zhang RZ, Gascon R, Miller RG, Gelinas DF, Mass J, Lancero M, Narvaez A, McGrath MS. MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (aALS). J Neuroimmunol;179(2006)87-93 link
  77. Contreras-Galindo R, Kaplan MH, Markovitz DM, Lorenzo E, Yamamura Y. Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2006 Oct;22(10):979-84.
  78. Carroll PA, Kenerson HL, Yeung RS, Lagunoff M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol. 2006 Nov;80(21):10802-12. Epub 2006 Sep 6.
  79. Kadoch C, Treseler P, Rubenstein JL Molecular pathogenesis of primary central nervous system lymphoma. Neurosurg Focus. 2006 Nov 15;21(5):E1. Review
  80. Geraci-Erck MA, Tiant M, Gessford MK, Lee KB, Losco PE. A Histopathologic and Immunohistochemical Comparison Between Virus-Associated Fibroproliferative Disorders in Cynomolgus Monkeys and Human Kaposi's Sarcoma. J Histotechnol. 2007:30(3):199.
  81. Hansen A, Boshoff C, Lagos D. Kaposi sarcoma as a model of oncogenesis and cancer treatment. Expert Rev Anticancer Ther. 2007 Feb;7(2):211-20. Review.
  82. Lagos D, Trotter MW, Vart RJ, Wang HW, Matthews NC, Hansen A, Flore O, Gotch F, Boshoff C. Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells. Blood. 2007 Feb 15;109(4):1550-8. Epub 2006 Oct 17. link
  83. Leona W Ayers , Sylvia Silver , Michael S McGrath and Jan M Orenstein. The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery. link
  84. Vart RJ, Nikitenko LL, Lagos D, Trotter MW, Cannon M, Bourboulia D, Gratrix F, Takeuchi Y, Boshoff C. Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res. 2007 May 1;67(9):4042-51.
  85. Mutlu AD, Cavallin LE, Vincent L, Chiozzini C, Eroles P, Duran EM, Asgari Z, Hooper AT, La Perle KM, Hilsher C, Gao SJ, Dittmer DP, Rafii S, Mesri EA. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007 Mar;11(3):245-58. Erratum in: Cancer Cell. 2007 May;11(5):471.
  86. Shiramizu B, Hu N, Frisque RJ, Nerurkar VR High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. Cell Mol Biol (Noisy-le-grand). 2007 May 15;53(3):4-12.
Abstracts
  1. Mack K, Wei R, Shiramizu B, Herndier B, Elbaggari A, Gascon R, Hurt M, McGrath MS. “Sequential Pathogenesis” of AIDS malignancies: Clonal insertion of HIV into macrophages may serve as an early neoplastic event. Keystone Symposia on Molecular and Cellular Biology Park City, UT, March 13-19, 1998
  2. Flickinger M, McGrath M, Silver S, Orenstein J, Miles S, Ayers LW. AIDs malignancy bank: a source for tissue and biological fluids of HIV-related malignancies. 12th World AIDS Conference Geneva, Switzerland, June 28 - July 3, 1998 link
  3. Ayers LW, McGrath MS, Silver S, Miles S, Axiotis C. The AIDS and Cancer Specimen Bank (ACSB), A NCI Tissue and Biological Fluids Bank of HIV Infected Tissues. In The 3rd National AIDS Malignancy Conference. Bethesda, Maryland, USA. May 26-27, 1999. Abstracts. J Acquir Immune Defic Syndr. 1999 May 1;21(1):A1-41. link
  4. Flickinger M, McGrath M, Silver S, Orenstein J, Miles S, Ayers LW, Axiotis C. Tissue and biological fluids banks of HIV-related malignancies. In The 3rd National AIDS Malignancy Conference. Bethesda, Maryland, USA. May 26-27, 1999. Abstracts. J Acquir Immune Defic Syndr. 1999 May 1;21(1):A1-41. link
  5. Flickinger M, McGrath M, Silver S, Orenstein J, Miles S, Ayers LW. AIDS Malignancy Bank: a source for tissue and biological fluids of HIV-related malignancies. In Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. link
  6. Herndier B, Wei R, Abbey N, Weinstein M, Mack K, Shiramizu B, McGrath MS. Kaposi’s sarcoma: a multicellular, mulitviral process initiated by retroviral insertional mutagenesis?. In Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. link
  7. Mack K, Wei R, Shiramizu B, Herndier B, Elbaggari A, Gascon R, Hurt M, McGrath MS. Evidence for HIV mediated cis-activation of the c-fes protooncogene in a subset of AIDS associated lymphomas. In Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. link
  8. Mallery SR, Clark YM, Ness GM, Ayers LW and CM Hohl. AIDS-Kaposi's Sarcoma Demonstrate Increased Susceptibility to a Redox Cycling Drug. In Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. link
  9. McGrath MS, Shiramizu B, McGuire D, Pulliam L, Herndier B. HIV-associated neoplastic dementia: A model implicating a role for clonal macrophages. In Proceedings of the Second National AIDS Malignancy Conference. Bethesda, Maryland, USA. April 6-8, 1998. J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S1-86. link
  10. Parris L, Ayers LW. Iron Loading of Alveolar Macrophages in HIV Positive Patients. The MRI Science Symposium, Medical/Science Research Initiative, (MRI), Office of Minority Affairs Columbus, OH, August 1999
  11. Abbey NW, McGrath MS, Herndier BG. C-fes proto-oncogene expression in HIV and non-HIV lymphoid tissues. Seventh Conference on Retroviruses and Opportunistic Infections San Francisco, CA, January 30 – February 2, 2000 link
  12. Mack KD, Wei R, Herndier B, Shiramizu B, Abbey N, Gascon R, Elbaggari A, Hurt M, Earnst T, McGrath MS. HIV implicated in the cis-activation of c-fes in a subset of HIV associated lymphomas. Seventh Conference on Retroviruses and Opportunistic Infections San Francisco, CA, January 30 – February 2, 2000 link
  13. Ayers LW, and The Midregion ACSB Consortium. The Ohio State University, Emory University, Rush University, University of Texas, Southwestern and Vanderbilt University: Application of the Tissue Microarray (TMA) method by the Midregion AIDS and Cancer Specimen Bank (ACSB) to prepare study sets from HIV infected and control tissues. In The 4th International AIDS Malignancy Conference. Bethesda, Maryland, USA. May 16-18, 2000. Abstracts. J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):A1-37. link
  14. McGrath MS, Elbaggari A, Gascon R, Herndier B, Meuer S, Giese T, Zenger E. Quantitation of AIDS lymphoma associated macrophage RNA. implications for “sequential pathogenesis” of extranodal lymphoma. In The 4th International AIDS Malignancy Conference. Bethesda, Maryland, USA. May 16-18, 2000. Abstracts. J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):A1-37. link
  15. Davis, AT, Mosunjac MB. Cervical dysplasia in women infected with human immunodeficiency virus {HIV): a correlation with HIV viral load. United States and Canadian Association of Pathology meeting New Orleans, LA, March 2000 link
  16. Abbey NW, Silver S, Orenstein JM, Miles S, Ayers L, Axiotis C, McGrath MS. The AIDS and Cancer Specimen Bank. In The 4th International AIDS Malignancy Conference. Bethesda, Maryland, USA. May 16-18, 2000. Abstracts. J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):A1-37. link
  17. Davis, AT, Walliang R, Mosunjac MI, Mosunjac MB. Human immunodeficiency virus (HIV)-associated premalignant and malignant lesions by gender in a large inner-city hospital: a retrospective study. United States and Canadian Academy of Pathology Annual Meeting New Orleans, LA, March 25-31, 2000
  18. Ayers LW, Romer D, Yi H, The Midregion AIDS and Cancer Specimen Bank (ACSB). Cancer Research Data from Tissue Microarrays (TMA) and the Associated Patient Demographic and Clinical Information Facilitated by a Graphical Microsoft Access Database. Cancer research data from tissue microarrays (TMA) and the associated patient demographic and clinical information facilitated by a graphical Microsoft Access database. Third Annual Comprehensive Cancer Center Scientific Meeting Dublin, OH, January 24, 2001
  19. Ayers LW, Romer D, Yi H, and The Midregion AIDS and Cancer Specimen Bank (ACSB), and Division of Informatics, Department of Pathology, The Ohio State University, Columbus, OH 43210. AIDS-Associated Malignant Tissue Research using Tissue Micro-Arrays (TMAs) Facilitated by a Graphical Microsoft Access Database. Fifth International AIDS Malignancy Conference Bethesda, MD, April 23-26, 2001
  20. Garcia D, McGrath MS, Silver S, Miles S, Ayers L, Axiotis C. AIDS and Cancer Specimen Bank. Fifth International AIDS Malignancy Conference Bethesda, Maryland, 26, April 23-25, 2001
  21. Garcia DL, McGrath MS, Silver S, Orenstein J, Ayers L. AIDS and Cancer Specimen Bank. The XIV International AIDS Conference, 2002 Abstract no. C11034. link
  22. Ayers LW, Romer D, Yi H. The Midregion AIDS and Cancer Specimen Bank (ACSB). A Tissue Array Database System (TADS) for the AIDS Cancer and Specimen Bank (ACSB) Developed to Manage Numerical and Digital Image Cancer Research Data From Tissue Microarrays (TMAs). The Fourth Annual Comprehensive Cancer Center Scientific Meeting Dublin, OH, January 11, 2002
  23. Mihm M, Schanbacher BL, Basuray A, Lui C, Amann DM, Ayers LW, John Anthony Bauer, JA. Protein Oxidation and Immune Cell Trafficking in Human AIDS-Related Cardiomyopathy. The Ohio State University Medical Center Graduate and Postgraduate Research Day April 4, 2002
  24. Romer D, Ayers L. Adding a Robotic Stage to the Desktop Microscope and Creating Virtual Slides with Image Pro Plus. In Advancing Pathology Informatics, Imaging, and the Internet (APIII 2001). Arch Pathol Lab Med. 2002 Jul;126(7):792. link
  25. Ayers L, Romer D. Development of a Tissue Array Data System (TADS) for AIDS and Cancer Specimen Bank (ACSB). In Advancing Pathology Informatics, Imaging, and the Internet (APIII 2001). Arch Pathol Lab Med. 2002 Jul;126(7):791–792.